Department of Integrative Medical Biology

Umeå University is one of Sweden’s largest institutions of higher education with over 35,000 students and 4,200 faculty and staff. We are characterised by world-leading research in several scientific fields and a multitude of educations ranked highly in international comparison. Umeå University is also the site of the pioneering discovery of the CRISPR-Cas9 genetic scissors - a revolution in genetic engineering that has been awarded the Nobel Prize in Chemistry.

At Umeå University, everything is nearby. Our cohesive campus environment makes it easy to meet, collaborate and exchange knowledge, which promotes a dynamic and open culture where we rejoice in each other's successes.

The Faculty of Medicine, which consists of 13 departments, is responsible for biomedical research and courses in the field of nursing and health care and has an extensive research and graduate education in more than 80 subjects.

Description of the PhD-project:

 The project involves work with culture of human stem cells (iPSCs) and the differentiation of these to neurons and other brain cell types to study disease processes in amyotrophic lateral sclerosis (ALS). The goal of the project is to understand how the unfolding and aggregation of the SOD1 protein leads to motor neuron cytotoxicity in ALS by studying in vitro models and using biochemical methods and also live cell imaging of axonal transport. A strong background in cell biology and cell-based assays is essential for the project; also experience working with DNA cloning, recombinant proteins, protein biochemistry and protein aggregation.


Applicants must 1) hold a University degree of at least 240 ECTS or equivalent or 2) have 120 Swedish (old) credits (Swe. poäng; corresponding to 180 ECTS credits) of higher education studies in the same fields or equivalent taken before July 1, 2007.

Other merits:

In addition, the applicant should, through university studies or other equivalent education, have gained basic theoretical knowledge in biomedicine and have good experience of laboratory work and method development. Applicants with practical experience of research with human stem cells/iPSCs, in vitro differentiation and culture, or neuronal cells, or work with neuronal cell lines will be prioritized. Experience of protein biochemistry and analysis of proteins using e.g. ELISA, western blotting and immunohistochemistry and other biochemical methods of analysis are also considered strengths. Experience in fluorescence microscopy is also considered as strength. The applicant must be able to work both independently and as part of a team, and high focus will be given to the candidate’s potential to work with others and also their ability to write scientific text.

Specific admission requirements:

In order to be admitted to postgraduate studies, it is required that the
applicant has:

Necessary knowledge from university higher education or corresponding education and/or special professional experience that is assessed in relation to the research area.

Necessary English language skills, both in writing and in speaking. Evaluation of these skills is made by having the intended PhD student present his/her research plan in English for the Department’s designated postgraduate education group.

Further information: Senior Lecturer Jonathan Gilthorpe,

Start date: 2020-04-01, or upon agreement.

Other information:

The procedure for recruitment for the position is in accordance with the Higher Education Ordinance (chapt. 12, 2 §) and the decision regarding the position cannot be appealed.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment April 1st, or upon agreement.
Salary Monthly salary
Number of positions 1
Working hours 100%
City Umeå
County Västerbottens län
Country Sweden
Reference number AN 2.2.1-131-20
  • Universitetslektor Jonathan Gilthorpe,
Union representative
  • SACO, 090-786 53 65
  • SEKO, 090-786 52 96
  • ST, 090-786 54 31
Published 31.Jan.2020
Last application date 18.Feb.2020 11:59 PM CET

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