PhD student position in Medical Science with an orientation towards Cell Biology and with focus on protein structure determination using cryo-electron microscopy - Befattningen är under tillsättning eller redan tillsatt, och det är inte längre möjligt att lämna in en ansökan
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Umeå University, Medicinska fakulteten
Umeå University is one of Sweden’s largest higher education institutions with over 37,000 students and about 4,700 employees. The University offers a diversity of high-quality education and world-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything is close. Our cohesive campuses make it easy to meet, work together and exchange knowledge, which promotes a dynamic and open culture.
The ongoing societal transformation and large green investments in northern Sweden create enormous opportunities and complex challenges. For Umeå University, conducting research about – and in the middle of – a society in transition is key. We also take pride in delivering education to enable regions to expand quickly and sustainably. In fact, the future is made here.
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The Faculty of Medicine, which consists of 13 departments, is responsible for biomedical research and courses in the field of nursing and health care and has an extensive research and graduate education in more than 80 subjects.
Description of the PhD-project:
Flaviviruses such as dengue virus, yellow fever virus, Zika virus and tick-borne encephalitis virus (TBEV) cause severe disease in humans. Flaviviruses replicate their RNA genome in infected cells by generating small cavities in cellular membranes, called replication compartments (RCs). The RCs are formed in response to the expression of viral proteins and this process is absolutely essential for the propagation and transmission of viruses. This PhD project aims at applying cryo-electron microscopy and correlative imaging techniques to resolve the structural composition of replication compartments formed by TBEV in cells. Special focus is given to focused ion-beam (FIB) technology and cryo-electron tomography in combination with light microscopy with the aim to precisely map the supramolecular arrangement of viral proteins in RC´s inside cells. We use specially designed non-infectious cell-model systems. The gained mechanistic understanding of how RCs are formed will be instrumental to the combat of flavivirus infections.
For more information regarding the research group and our research projects please see: http://lundmark-lab.se/ and https://www.umu.se/en/staff/richard-lundmark/
Qualifications:
Applicants must 1) hold a University degree of at least 240 ECTS or equivalent or 2) have 120 Swedish (old) credits (Swe. poäng; corresponding to 180 ECTS credits) of higher education studies in the same fields or equivalent taken before July 1, 2007.
Other merits:
Bbasic theoretical knowledge in biomedicine and protein and lipid biochemistry, gained through university studies or other equivalent education, as well as thoroug experience in laboratory work is of merit value. Applicants with practical experience of work with genetic modification of cell-based model systems and protein and lipid biochemistry are prioritized. Experience from working with light and or cryo-EM as well as protein crystallography is also of merit value. The applicant must be able to work both independently and as part of a team, and high focus will be given to the candidate’s potential collaborative skills.
Further information: Dr. Richard Lundmark, email: richard.lundmark@umu.se
Start date: 2019-12-01, or upon agreement.
Other information:
https://www.umu.se/en/research/doctoral-studies/
| Type of employment | Temporary position |
|---|---|
| Contract type | Full time |
| Salary | Monthly salary |
| Number of positions | 1 |
| Full-time equivalent | 100% |
| City | Umeå |
| County | Västerbottens län |
| Country | Sweden |
| Reference number | AN 2.2.1-1444-19 |
| Contact |
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| Union representative |
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| Published | 03.Oct.2019 |
| Last application date | 28.Oct.2019 11:59 PM CET |