Umeå University, Medicinska fakulteten

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The Faculty of Medicine, which consists of 13 departments, is responsible for biomedical research and courses in the field of nursing and health care and has an extensive research and graduate education in more than 80 subjects.

Description of the PhD-project:

Flaviviruses such as dengue virus, yellow fever virus, Zika virus and tick-borne encephalitis virus (TBEV) cause severe disease in humans. Flaviviruses replicate their RNA genome in infected cells by generating small cavities in cellular membranes, called replication compartments (RCs). The RCs are formed in response to the expression of viral proteins and this process is absolutely essential for the propagation and transmission of viruses.  This PhD project aims at applying cryo-electron microscopy and correlative imaging techniques to resolve the structural composition of replication compartments formed by TBEV in cells.  Special focus is given to focused ion-beam (FIB) technology and cryo-electron tomography in combination with light microscopy with the aim to precisely map the supramolecular arrangement of viral proteins in RC´s inside cells. We use specially designed non-infectious cell-model systems. The gained mechanistic understanding of how RCs are formed will be instrumental to the combat of flavivirus infections.

For more information regarding the research group and our research projects please see:  http://lundmark-lab.se/ and https://www.umu.se/en/staff/richard-lundmark/

Qualifications:

Applicants must 1) hold a University degree of at least 240 ECTS or equivalent or 2) have 120 Swedish (old) credits (Swe. poäng; corresponding to 180 ECTS credits) of higher education studies in the same fields or equivalent taken before July 1, 2007.

Other merits:

Bbasic theoretical knowledge in biomedicine and protein and lipid biochemistry, gained through university studies or other equivalent education, as well as thoroug experience in laboratory work is of merit value. Applicants with practical experience of work with genetic modification of cell-based model systems and protein and lipid biochemistry are prioritized. Experience from working with light and or cryo-EM as well as protein crystallography is also of merit value. The applicant must be able to work both independently and as part of a team, and high focus will be given to the candidate’s potential collaborative skills.

Further information: Dr. Richard Lundmark, email: richard.lundmark@umu.se

Start date: 2019-12-01, or upon agreement.


Other information:
https://www.umu.se/en/research/doctoral-studies/

Type of employment Temporary position longer than 6 months
Contract type Full time
Salary Monthly salary
Number of positions 1
Working hours 100%
City Umeå
County Västerbottens län
Country Sweden
Reference number AN 2.2.1-1444-19
Contact
  • Universitetslektor Richard Lundmark, richard.lundmark@umu.se
Union representative
  • SACO, 090-786 53 65
  • SEKO, 090-786 52 96
  • ST, 090-786 54 31
Published 03.Oct.2019
Last application date 28.Oct.2019 11:59 PM CET

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