Senior research engineer - ,
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Umeå University, Medicinska fakulteten
Umeå University is one of Sweden’s largest higher education institutions with over 37,000 students and about 4,700 employees. The University offers a diversity of high-quality education and world-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything is close. Our cohesive campuses make it easy to meet, work together and exchange knowledge, which promotes a dynamic and open culture.
The ongoing societal transformation and large green investments in northern Sweden create enormous opportunities and complex challenges. For Umeå University, conducting research about – and in the middle of – a society in transition is key. We also take pride in delivering education to enable regions to expand quickly and sustainably. In fact, the future is made here.
Are you interested in learning more? Read about Umeå university as a workplace
The Faculty of Medicine, which consists of 12 departments, is responsible for biomedical research and courses in the field of nursing and health care and has an extensive research and graduate education in more than 80 subjects.
The Department of Clinical Science, Neurosciences, is recruiting a senior research engineer to work on a project focused on validation of biomarkers for neurodegenerative diseases.
Research within the Department of Clinical Science, Neurosciences is focused on understanding molecular etiologies of neurological diseases towards improving patient diagnosis and care. The department has research laboratories within the Translational Research Centre at Norrlands University Hospital and mass spectrometry analysis will be performed in the Chemical Biological Centre at the Swedish Metabolomics Centre (www.swedishmetabolomicscentre.se/). By offering a broad range of cutting-edge mass spectrometry capabilities in the context of research in life science and medicine, this interdisciplinary environment facilitates collaborative efforts to improve chemical analysis of clinical samples.
The position is for 11 months. The project period will begin as soon as possible according to agreement.
Project Description
The neurodegenerative diseases ALS, Alzheimer’s and Parkinson’s disease all involve progressive spread of aggregated proteins and neuronal loss. Our goal is to identify and validate early stage biomarker candidates and novel therapeutic targets. This work involves proteomic profiling and targeted multiple reaction monitoring (MRM) assays in cerebral spinal fluid (CSF) and blood from patients, including pre-symptomatic samples. Focus is mainly on LC-MS analysis, but additional methods will be used for validation of clinically useful diagnostics and candidate therapeutic targets.
Qualifications
The required academic qualification is a doctoral degree in analytical chemistry focused on mass spectrometry method development. Extensive experience in sample preparation for proteins in biofluids, running LC-MS instruments and proteomics data analysis is required. Candidates with documented experience using MRM assays for biomarker validation are preferred. And previous experience in CSF and blood analysis for neurodegenerative diseases is an advantage. The research environment functions in the English language, so strong verbal and written skills are required.
Application
The application should include:
• A cover letter including your qualifications and research interests (less than one page)
• A Curriculum Vitae including a list of publications
• References should be available upon request
Welcome with your application!
| Type of employment | Temporary position |
|---|---|
| Contract type | Full time |
| First day of employment | 2021-02-05 |
| Salary | Monthly salary |
| Number of positions | 1 |
| Full-time equivalent | 100 |
| City | Umeå |
| County | Västerbottens län |
| Country | Sweden |
| Reference number | AN 2.2.1-1678-20 |
| Contact |
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| Union representative |
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| Published | 07.Dec.2020 |
| Last application date | 04.Jan.2021 11:59 PM CET |